Fresh approaches to familiar and emerging societal challenges rely on a willingness to be audacious, to tackle familiar issues in novel ways, and to imagine a more equitable world. Health, Medicine & Society believes that provocative conversations and action-oriented solutions will allow us to address health issues long considered intractable, tackle looming problems before they pose acute dangers to individuals and populations, and elevate prevention, rather than treatment, as a goal. Asking hard questions, bringing together experts and thinkers across disciplines, and including the voices of those who are most affected by health system challenges are pathways to innovative solutions.