When the first pandemic in a century swept across the globe, public health professionals understood that an array of action steps would be necessary to combat it. Over time, their response evolved to incorporate or consider lockdowns; control measures, such as masks and social distancing; equitable access to vaccines; risk assessments; and strategies for learning to live with the virus. Health, Medicine & Society has been engaged at every step, bringing experts together to consider best practices, develop effective messages, and plan for future infectious diseases.