Despite having the most complex and costly healthcare infrastructure in the world, the U.S. lags behind many other wealthy nations in numerous population health indicators. Maternal mortality rates are high and the toll of chronic disease and opioid use is chilling. End-of-life care and healthcare in jails and prisons do grave injustices to vulnerable populations and antimicrobial resistance threatens the planet. Health, Medicine & Society brings together doers and thinkers to envision and implement actionable strategies to strengthen health systems and services and confront the challenges.